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The term "scientific instrumentation" covers a variety of different applications, starting with microscopy via beamline processes through to the wide field of laboratory automation. They all have one thing in common: Precise and mainly piezo-based positioning systems have proven their value under extremely varying conditions of use. Parallel-kinematic systems are the system of choice for multi-axial solutions. Even payloads weighing tons can be positioned with micrometer precision with their help.